Medicinal Chemistry (MCCF) Core
About the MCCF Core Facility
The Max and Minnie Tomerlin Voelcker Medicinal Chemistry Core Facility (MCCF) at UTSA is a 2000 sq. ft. state-of-the-art technological center located on the west campus of UTSA that performs all necessary chemistry and synthesis services to support a large diversity of small molecule drug discovery efforts.
The MCCF will provide custom synthesis and medicinal chemistry research for small molecule drug discovery projects in any therapeutic area. The center will also provide collaboration, consultation and program strategy opportunities from investigators who have over 25 years of pharmaceutical experience in taking small molecule compounds through all stages of the pre-clinical drug discovery process.
Goal and Vision
The ultimate intent of the CIDD is to provide a diverse array of core facilities and expertise to facilitate the translation of basic scientific discoveries into tangible pre-clinical candidate drugs that can be further developed into clinical therapies for human disease.
People
Co-Director of the Center for Innovative Drug Discovery (CIDD)
Associate Professor, Department of Chemistry at The University of Texas at San Antonio
Research Capabilities:
- Collaborative research opportunities involving synthesis, medicinal chemistry and drug discovery areas
- Custom synthesis of non-commercial small molecules from milligram to multi-gram quantities
- Design of “drug-like” molecules and analysis of physical chemical properties
- Structure-based drug design
- Full service medicinal chemistry suite, i.e. hit-to-lead activities, small library design and synthesis, de novo analog design and synthesis, structure-activity relationships (SAR)
- Analytical chemistry support, including drug stability, solubility and structural determinations
- Synthetic route process development, improvement and scale up of biologically active compounds
- Consultation, planning and strategy development for advancing small molecule drug discovery programs; including medicinal chemistry, ADME issues, pk/pd, toxicology, formulation, drug exposure and dosing options